Ricolinostat Reduces Pain in Diabetic Peripheral Neuropathy

  • Injection of streptozotocin ablates pancreatic beta cells, eliminates insulin production, and causes a rapid, severe rise in blood glucose
  • Rats develop pain in the feet similar to painful neuropathy in Type I diabetic patients
    • Pain in rats is detected by measuring the force needed to elicit a paw withdrawal (Force of Withdrawal)
  • Similarly to gabapentin, ricolinostat reversed neuropathic pain
  • Unlike gabapentin, the effect of ricolinostat persists for days after the end of dosing